Totsberry PD Syrup

Category

Syrups

Description

Therapy/Class: Mucolytic/Expectorant

Therapy / Class

Therapy

• Ambroxol: Mucolytic Agent
• Guaiphenesin: Expectorant
• Levosalbutamol: Bronchodilators

Class

• Ambroxol: Aromatic Benzylamine
• Guaiphenesin: Glyceryl Guaiacolate
• Levosalbutamol: Beta2-Adrenergic Receptors agonist

Mechanism of Action

Ambroxol: It has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.

Guaiphenesin: It acts by enhancing the output of phlegm (sputum) and bronchial secretions via decreasing the adhesiveness and surface tension of such material. Furthermore, it elicits an increased flow of less viscous gastric secretions that subsequently promote ciliary action - all actions that ultimately change dry, unproductive coughing to coughs that are more productive and less frequent. Essentially, by decreasing the viscosity and adhesiveness of such secretions, it enhances the efficacy of mucociliary activity in removing accumulated secretions from the upper and lower airway.

Levosalbutamol:It activates beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenyl cyclase and to an increase in the intracellular concentration of cyclic-3', 5'-adenosine monophosphate (cyclic AMP). The increase in cyclic AMP is associated with the activation of protein kinase A, which, in turn, inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in muscle relaxation. It relaxes the smooth muscles of all airways, from the trachea to the terminal bronchioles. Increased cyclic AMP concentrations are also associated with the inhibition of the release of mediators from mast cells in the airways.

Indications

• Symptomatic relief of Bronchospasm in Bronchial Asthma & Chronic Bronchitis.
• Treatment of productive cough associated with...
• Bronchial Asthma
• Bronchitis
• Bronchiectasis
• Chronic Obstructive Pulmonary Diseases (COPD)
• Bronchitis (Inflammation of Bronchial Tubes)
• Emphysema (Shortness of Breath)
• Upper & Lower Respiratory Infections